机器学习（ML）具有改善医疗保健的巨大希望，但至关重要的是要确保其使用不会传播或扩大健康差异。一个重要的步骤是表征ML模型的（联合国）公平性 - 它们在人群的亚组中的表现趋势不同，并了解其潜在机制。当ML模拟培训数据中不正确相关性的基本预测时，就会出现算法不公平，快捷学习的潜在驱动力。但是，诊断这种现象很困难，尤其是当敏感属性与疾病有因果关系时。使用多任务学习，我们提出了第一种评估和减轻快捷方式学习的方法，作为临床ML系统公平评估的一部分，并证明了其在放射学和皮肤病学中的临床任务中的应用。最后，我们的方法揭示了捷径对不公平不公平负责的情况，强调了对医疗AI中的公平缓解的必要性。

语言模型既展示了定量的改进，又展示了新的定性功能，随着规模的增加。尽管它们具有潜在的变革性影响，但这些新能力的特征却很差。为了为未来的研究提供信息，为破坏性的新模型能力做准备，并改善社会有害的效果，至关重要的是，我们必须了解目前和近乎未来的能力和语言模型的局限性。为了应对这一挑战，我们介绍了超越模仿游戏基准（Big Bench）。 Big Bench目前由204个任务组成，由132家机构的442位作者贡献。任务主题是多样的，从语言学，儿童发展，数学，常识性推理，生物学，物理学，社会偏见，软件开发等等。 Big-Bench专注于被认为超出当前语言模型的功能的任务。我们评估了OpenAI的GPT型号，Google内部密集变压器体系结构和大型基础上的开关稀疏变压器的行为，跨越了数百万到数十亿个参数。此外，一个人类专家评估者团队执行了所有任务，以提供强大的基准。研究结果包括：模型性能和校准都随规模改善，但绝对的术语（以及与评估者的性能相比）；在模型类中的性能非常相似，尽管带有稀疏性。逐渐和预测的任务通常涉及大量知识或记忆成分，而在临界规模上表现出“突破性”行为的任务通常涉及多个步骤或组成部分或脆性指标；社交偏见通常会随着含糊不清的环境而随着规模而增加，但这可以通过提示来改善。

大型语言模型可以编码有关世界的大量语义知识。这种知识对于旨在采取自然语言表达的高级，时间扩展的指示的机器人可能非常有用。但是，语言模型的一个重大弱点是，它们缺乏现实世界的经验，这使得很难利用它们在给定的体现中进行决策。例如，要求语言模型描述如何清洁溢出物可能会导致合理的叙述，但是它可能不适用于需要在特定环境中执行此任务的特定代理商（例如机器人）。我们建议通过预处理的技能来提供现实世界的基础，这些技能用于限制模型以提出可行且在上下文上适当的自然语言动作。机器人可以充当语​​言模型的“手和眼睛”，而语言模型可以提供有关任务的高级语义知识。我们展示了如何将低级技能与大语言模型结合在一起，以便语言模型提供有关执行复杂和时间扩展说明的过程的高级知识，而与这些技能相关的价值功能则提供了连接必要的基础了解特定的物理环境。我们在许多现实世界的机器人任务上评估了我们的方法，我们表明了对现实世界接地的需求，并且这种方法能够在移动操纵器上完成长远，抽象的自然语言指令。该项目的网站和视频可以在https://say-can.github.io/上找到。

我们介绍了445名人员和计算机生成的文件的新型语料库，包括约27,000个条款，用于语义条款类型和相干关系，允许人工和自然话语模式的细节比较。该语料库涵盖了正式和非正式的话语，并包含使用微调GPT-2生成的文件（Zellers等，2019）和GPT-3（棕色等，2020）。我们通过提供初步证据，展示该语料库的有用性，通过提供初步证据，以提供较少，更短，更频繁的通电话条款关系与计算机生成的叙述和论点的较低质量相关。

最近已被证明大型语言模型在各种任务集中获得合理的零射普通化（Brown等，2020）。它已经假设这是语言模型的隐式多任务学习的结果，在语言模型中的预押（Radford等，2019）。可以通过明确的多任务学习直接引起零拍常规化？为了以缩放测试这个问题，我们开发一个系统，以便轻松地将任何自然语言任务映射到人类可读的提示表单中。我们转换一组大量的监督数据集，每个数据集都有多个提示，具有不同的措辞。这些提示的数据集允许基准测试模型执行完全看不见的任务的能力。我们介绍了一个普拉克尔编码器 - 解码器模型（Raffel等，2020; Lester等，2021），覆盖各种任务。该模型在多个标准数据集中达到强大的零点性能，通常优于其尺寸的型号超过16倍。此外，我们的方法对来自Big-替补基准测试的任务子集具有强烈性能，优于其尺寸的6倍。所有提示和培训的型号都可以在https://github.com/ bigscience-workshop / protectsource / httpsource / https：//huggingface.co/bigscience/t0pp。

In the past years, deep learning has seen an increase of usage in the domain of histopathological applications. However, while these approaches have shown great potential, in high-risk environments deep learning models need to be able to judge their own uncertainty and be able to reject inputs when there is a significant chance of misclassification. In this work, we conduct a rigorous evaluation of the most commonly used uncertainty and robustness methods for the classification of Whole-Slide-Images under domain shift using the H\&E stained Camelyon17 breast cancer dataset. Although it is known that histopathological data can be subject to strong domain shift and label noise, to our knowledge this is the first work that compares the most common methods for uncertainty estimation under these aspects. In our experiments, we compare Stochastic Variational Inference, Monte-Carlo Dropout, Deep Ensembles, Test-Time Data Augmentation as well as combinations thereof. We observe that ensembles of methods generally lead to higher accuracies and better calibration and that Test-Time Data Augmentation can be a promising alternative when choosing an appropriate set of augmentations. Across methods, a rejection of the most uncertain tiles leads to a significant increase in classification accuracy on both in-distribution as well as out-of-distribution data. Furthermore, we conduct experiments comparing these methods under varying conditions of label noise. We observe that the border regions of the Camelyon17 dataset are subject to label noise and evaluate the robustness of the included methods against different noise levels. Lastly, we publish our code framework to facilitate further research on uncertainty estimation on histopathological data.

Charisma is considered as one's ability to attract and potentially also influence others. Clearly, there can be considerable interest from an artificial intelligence's (AI) perspective to provide it with such skill. Beyond, a plethora of use cases opens up for computational measurement of human charisma, such as for tutoring humans in the acquisition of charisma, mediating human-to-human conversation, or identifying charismatic individuals in big social data. A number of models exist that base charisma on various dimensions, often following the idea that charisma is given if someone could and would help others. Examples include influence (could help) and affability (would help) in scientific studies or power (could help), presence, and warmth (both would help) as a popular concept. Modelling high levels in these dimensions for humanoid robots or virtual agents, seems accomplishable. Beyond, also automatic measurement appears quite feasible with the recent advances in the related fields of Affective Computing and Social Signal Processing. Here, we, thereforem present a blueprint for building machines that can appear charismatic, but also analyse the charisma of others. To this end, we first provide the psychological perspective including different models of charisma and behavioural cues of it. We then switch to conversational charisma in spoken language as an exemplary modality that is essential for human-human and human-computer conversations. The computational perspective then deals with the recognition and generation of charismatic behaviour by AI. This includes an overview of the state of play in the field and the aforementioned blueprint. We then name exemplary use cases of computational charismatic skills before switching to ethical aspects and concluding this overview and perspective on building charisma-enabled AI.

Deep learning-based 3D human pose estimation performs best when trained on large amounts of labeled data, making combined learning from many datasets an important research direction. One obstacle to this endeavor are the different skeleton formats provided by different datasets, i.e., they do not label the same set of anatomical landmarks. There is little prior research on how to best supervise one model with such discrepant labels. We show that simply using separate output heads for different skeletons results in inconsistent depth estimates and insufficient information sharing across skeletons. As a remedy, we propose a novel affine-combining autoencoder (ACAE) method to perform dimensionality reduction on the number of landmarks. The discovered latent 3D points capture the redundancy among skeletons, enabling enhanced information sharing when used for consistency regularization. Our approach scales to an extreme multi-dataset regime, where we use 28 3D human pose datasets to supervise one model, which outperforms prior work on a range of benchmarks, including the challenging 3D Poses in the Wild (3DPW) dataset. Our code and models are available for research purposes.

This article concerns Bayesian inference using deep linear networks with output dimension one. In the interpolating (zero noise) regime we show that with Gaussian weight priors and MSE negative log-likelihood loss both the predictive posterior and the Bayesian model evidence can be written in closed form in terms of a class of meromorphic special functions called Meijer-G functions. These results are non-asymptotic and hold for any training dataset, network depth, and hidden layer widths, giving exact solutions to Bayesian interpolation using a deep Gaussian process with a Euclidean covariance at each layer. Through novel asymptotic expansions of Meijer-G functions, a rich new picture of the role of depth emerges. Specifically, we find that the posteriors in deep linear networks with data-independent priors are the same as in shallow networks with evidence maximizing data-dependent priors. In this sense, deep linear networks make provably optimal predictions. We also prove that, starting from data-agnostic priors, Bayesian model evidence in wide networks is only maximized at infinite depth. This gives a principled reason to prefer deeper networks (at least in the linear case). Finally, our results show that with data-agnostic priors a novel notion of effective depth given by \[\#\text{hidden layers}\times\frac{\#\text{training data}}{\text{network width}}\] determines the Bayesian posterior in wide linear networks, giving rigorous new scaling laws for generalization error.

In this paper we study the smooth strongly convex minimization problem $\min_{x}\min_y f(x,y)$. The existing optimal first-order methods require $\mathcal{O}(\sqrt{\max\{\kappa_x,\kappa_y\}} \log 1/\epsilon)$ of computations of both $\nabla_x f(x,y)$ and $\nabla_y f(x,y)$, where $\kappa_x$ and $\kappa_y$ are condition numbers with respect to variable blocks $x$ and $y$. We propose a new algorithm that only requires $\mathcal{O}(\sqrt{\kappa_x} \log 1/\epsilon)$ of computations of $\nabla_x f(x,y)$ and $\mathcal{O}(\sqrt{\kappa_y} \log 1/\epsilon)$ computations of $\nabla_y f(x,y)$. In some applications $\kappa_x \gg \kappa_y$, and computation of $\nabla_y f(x,y)$ is significantly cheaper than computation of $\nabla_x f(x,y)$. In this case, our algorithm substantially outperforms the existing state-of-the-art methods.